GMI 研究資料 ›
癌症 / Cancer
肺癌、乳癌、頭頸癌等癌別，以及癌幹細胞、抗藥性、轉移與化療副作用（口腔黏膜炎）。
研究文獻 / Literature（24）
- 文獻2026
Ganoderma microsporum Immunomodulatory Protein (GMI) Enhances Phagocytosis by Suppressing STAT3/CD47 Signaling in EGFR-Mutant NSCLC Resistant to Gefitinib and Osimertinib
機轉標籤（2）
- 文獻2026
Ganoderma Microsporum immunomodulatory protein suppresses osteosarcoma growth through redox imbalance and ER stress-driven apoptosis
機轉標籤（1）
- 文獻2025
rFIP-GMI Suppresses IGF-1-Induced Invasion and Migration in Breast Cancer Cells via PI3K/Akt/β-Catenin Inhibition
機轉標籤（1）
- 文獻2025
GMI, a Fungal Immunomodulatory Protein From Ganoderma microsporum, Induces Different Cytotoxicity in Parental and Osimertinib-Resistant EGFR-Mutated Lung Cancer Cells via Apoptotic and Autophagic Cell Death
機轉標籤（3）
- 文獻2025
Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1
- 文獻2024
Integrin αV Inhibition by GMI, a Ganoderma Microsporum Immunomodulatory Protein, Abolish Stemness and Migration in EGFR-Mutated Lung Cancer Cells Resistant to Osimertinib
機轉標籤（1）
- 文獻2024
Ganoderma microsporum immunomodulatory protein combined with KRASG12C inhibitor impedes intracellular AKT/ERK network to suppress lung cancer cells with KRAS mutation
機轉標籤（1）
- 文獻2023
GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer
- 文獻2023
Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells
機轉標籤（1）
- 文獻2022
GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells
- 文獻2021
Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells
機轉標籤（2）
- 文獻2021
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells
機轉標籤（1）
- 文獻2020
CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum
機轉標籤（1）
- 文獻2019
Inhibition of proliferation and migration of melanoma cells by ketoconazole and Ganoderma immunomodulatory proteins
- 文獻2019
The Protective Role of GMI, an Immunomodulatory Protein From Ganoderma microsporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis
- 文獻2018
Ganoderma immunomodulatory protein and chidamide down-regulate integrin-related signaling pathway result in migration inhibition and apoptosis induction
機轉標籤（1）
- 文獻2018
GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells
機轉標籤（1）
- 文獻2018
Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells
機轉標籤（1）
- 文獻2017
GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition
機轉標籤（1）
- 文獻2015
Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells
機轉標籤（2）
- 文獻2015
GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells
機轉標籤（2）
- 文獻2012
Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum
機轉標籤（2）
- 文獻2011
GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells
機轉標籤（1）
- 文獻2010
A new immunomodulatory protein from <i>Ganoderma microsporum</i> inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells
機轉標籤（2）
已核准專利 / Granted patents（6）
- 專利20181 件核准
GMI 抑制癌幹細胞
專利涵蓋 GMI 用於抑制癌幹細胞的相關用途。
- USUS9937226B2（2018）GMIBIO
- 專利20171 件核准
GMI 難治／復發肺癌應用
專利涵蓋 GMI 於難治性或復發性肺癌相關用途。
- USUS9827288B2（2017）GMIBIO
- 專利20151 件核准
GMI 乳癌應用
專利涵蓋 GMI 於乳癌相關用途。
- USUS9018171B2（2015）GMIBIO
- 專利20151 件核准
GMI 多癌別應用（US）
專利涵蓋 GMI 於肺癌、乳癌、肝癌及大腸直腸癌等相關用途。
- USUS9161964B2（2015）GMIBIO
- 專利20131 件核准
GMI 肺癌應用
專利涵蓋 GMI 於肺癌相關用途。
- USUS8476238B2（2013）GMIBIO
- 專利20131 件核准
GMI 多癌別應用（TW）
專利涵蓋 GMI 於肺癌、頭頸癌、乳癌、膀胱癌、腦癌、肝癌及大腸癌等相關用途。
- TWTWI414307B（2013）GMIBIO